The fourth season of Gossip Girl, an American teen drama, consisted of 22 episodes which aired between September 13, 2010 and May 16, 2011. The series was based upon the book series by Cecily von Ziegesar and developed for television by Josh Schwartz and Stephanie Savage. The CW officially renewed the series for a full fourth season on February 16, 2010. Blake Lively, Leighton Meester, Penn Badgley, Chace Crawford, Taylor Momsen, Ed Westwick, Jessica Szohr, Kelly Rutherford, and Matthew Settle all return as series regulars.

The first half of the season focuses on Juliet, a mysterious girl with a vendetta against Serena. The second half focuses on Chuck’s professional struggles trying to keep his father’s business from his father’s old rival and his relationship with Blair. The season also focuses on Blair’s relationship with a prince, Nate revisiting old family problems, the deteriorating friendship between Dan and Vanessa and his growing feelings for Blair, as well as Serena’s cousin Charlie and her integration into the Upper East Side.